TEST YOUR KNOWLEDGE
TEST YOUR KNOWLEDGE
Pathogenic IgG autoantibodies target vital components of the neuromuscular junction (NMJ), including acetylcholine receptors (AChR), muscle-specific tyrosine kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LRP4).2
In targeting the NMJ, pathogenic IgG autoantibodies disrupt neuromuscular transmission and drive the skeletal muscle weakness that defines gMG.3,4 Therefore, it may be worth exploring strategies that modulate the recycling of IgG antibodies by FcRn.1
References: 1. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715-725. doi:10.1038/nri2155 2. Gilhus NE et al. Nat Rev Neurol. 2016;12(5):259-268. doi:10.1038/nrneurol.2016.44 3. Huijbers MG et al. J Intern Med. 2014;275(1):12-26. doi:10.1111/joim.12163 4. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678